Fine-grained address space layout randomization (ASLR) has recently been proposed as a method of efficiently mitigating runtime attacks. In this presentation, we introduce the design and implementation of a framework based on a novel attack strategy, dubbed just-in-time code reuse, which both undermines the benefits of fine-grained ASLR and greatly enhances the ease of exploit development on today's platforms that combine standard ASLR and DEP (e.g. Windows 8). Specifically, we derail the assumptions embodied in fine-grained ASLR by exploiting the ability to repeatedly abuse a memory disclosure to map an application's memory layout on-the-fly, dynamically discover API functions and gadgets, and JIT-compile a target program using those gadgets-- all within a script environment at the time an exploit is launched. We demonstrate the power of our framework by using it in conjunction with a real-world exploit against Internet Explorer, show its effectiveness in Windows 8, and also provide extensive evaluations that demonstrate the practicality of just-in-time code reuse attacks. Our findings suggest that fine-grained ASLR may not be as promising as first thought.